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In individuals who are deficient in CYP2D6, coadministration of modafinil with substrates of CYP2D6 which have ancillary routes of elimination by way of CYP2C19 (eg, tricyclic antidepressants and selective serotonin reuptake inhibitors) could bring on elevated circulating amounts of these medicines and need dose adjustment (Robertson et al 2000; PR… Read More

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